Magdalena is a highly talented Master's student in the Master program Neuroscience at the University of Vienna. She is reprogramming patient-derived PBMCs and has established regionally specified brain organoids (forebrain and brainstem) from our patient-derived iPSCs.

She has been able to show that patient-derived forebrain organoids develop hyperproliferative zones and tumor-like lesions, while at the same time displaying a dysintegration of rosettes. During her thesis, she was able to assess whether brain organoids with distinct regional patterning show different dynamics in tumor initiation and has applied distinct transcriptomics approaches to unravel the molecular profile of her patient-derived organoids.

Eviana is a Master's student from the University of Cologne, who performed pluripotency validation in one of our patient-derived iPSC lines. She could also show comparable behavior of healthy donor-derived iPSCs and patient-derived iPSCs in terms of proliferation rate, expression of pluripotency markers and ability to give rise to cerebral organoids.

Maximilan attends Med School at the Medical University of Vienna. He has performed histological stainings for H3K27me3 on human fetal cerebellar tissue, where he observed dynamic, cell type-specific changes in H3K27me3 levels in the course of cerebellar development. He also became interested in a rare cerebellar malformation called rhomboencephalosynapsis, which shows distinct H3K27me3 levels.